Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two related neurodegenerative disorders. ALS and FTD have overlapping molecular causes and disease mechanisms. In the lab, we aim to gain insight into the disease mechanisms of neurodegeneration using various disease models.

Axonal degeneration of the motor axon is the main characteristic of Charcot-Marie-Tooth disease and of distal hereditary motor neuropathies (distal HMN). The laboratory focuses on the pathogenic mechanisms underlying these diseases.

Stroke is a very common disease and is the main cause of adult disability worldwide.  The laboratory focuses on new therapeutic strategies for ischemic stroke, the most common subtype.